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Cold Agglutinin Disease
Cold agglutinin disease, also called cold antibody disease or cold
antibody hemolytic anemia, is an autoimmune disease in which the body develops antibodies that attack red blood cells at room
temperature or colder. The condition is more likely to attack cooler parts of the body like the fingers, nose, and ears. Cold
agglutinin disease typically first appears in people over the age of 40.
Signs and Symptoms:
- Fatigue
- Anemia caused by low levels of circulating red blood cells
- Jaundice characterized by persistent yellowing of the skin, mucous
membranes and whites of the eyes
- Sweating and coldness of the fingers and/or toes
- Uneven bluish or reddish discoloration of the skin of the fingers
toes, ankles, and wrists
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